NGS Oncopanel 2

Panel naam	NGS Oncopanel 2
Panel methode	Wes-based NGS
Panel versie **	v7.1
Panel kwaliteit ***	C
Core-NL	Geen core-NL genen inbegrepen
CNV analyse	Nee
Locatie	Locatie VUmc

Genen (155)	Kwaliteit	% coverage >30	% coverage >20	Core-NL	Notitie
ABRAXAS1	C	99.99	100.00		NM_139076.3
ACD	C	100.00	100.00		NM_001082486.2
AIP	C	100.00	100.00		NM_003977.2
AKT1	C	100.00	100.00		NM_001382430.1
ALK	C	100.00	100.00		NM_004304.5
ANKRD26	C	98.02	98.03		NM_014915.3
APC	C	100.00	100.00		NM_000038.6
ATM	C	100.00	100.00		NM_001351834.2
AXIN2	C	100.00	100.00		NM_004655.4
BAP1	C	100.00	100.00		NM_004656.4
BARD1	C	100.00	100.00		NM_000465.4
BLM	C	100.00	100.00		NM_000057.4
BMPR1A	C	99.93	100.00		NM_004329.3
BRCA1	C	99.99	100.00		NM_007294.4
BRCA2	C	100.00	100.00		NM_000059.4
BRIP1	C	99.99	100.00		NM_032043.3
BUB1B	C	100.00	100.00		NM_001211.6
BUB3	C	100.00	100.00		NM_004725.4
CBL	C	100.00	100.00		NM_005188.4
CDC73	C	100.00	100.00		NM_024529.5
CDH1	C	100.00	100.00		NM_004360.5
CDK4	C	100.00	100.00		NM_000075.4
CDKN1A	C	100.00	100.00		NM_000389.5
CDKN1B	C	100.00	100.00		NM_004064.5
CDKN1C	C	94.92	98.33		NM_001122630.2
CDKN2A	C	100.00	100.00		NM_000077.5
CDKN2B	C	100.00	100.00		NM_004936.4
CDKN2C	C	99.82	100.00		NM_078626.3
CEBPA	C	99.62	99.97		NM_004364.5
CHEK2	C	100.00	100.00		NM_007194.4
CTC1	C	100.00	100.00		NM_025099.6
CTNNA1	C	100.00	100.00		NM_001903.5
CTR9	C	100.00	100.00		NM_014633.5
CYLD	C	99.96	100.00		NM_001378743.1
DDB2	C	100.00	100.00		NM_000107.2
DDX41	C	100.00	100.00		NM_016222.4
DICER1	C	100.00	100.00		NM_177438.3
DIS3L2	C	100.00	100.00		NM_152383.5
DKC1	C	99.7	99.92		NM_001363.5
DOCK8	C	100.00	100.00		NM_203447.4
EGFR	C	99.93	100.00		NM_005228.5
EPCAM	C	99.99	100.00		NM_002354.3
ERCC2	C	100.00	100.00		NM_000400.4
ERCC3	C	100.00	100.00		NM_000122.2
ERCC4	C	99.99	100.00		NM_005236.3
ERCC5	C	100.00	100.00		NM_000123.4
ETV6	C	100.00	100.00		NM_001987.5
EXT1	C	100.00	100.00		NM_000127.3
EXT2	C	100.00	100.00		NM_207122.2
FAAP100	C	100.00	100.00		NM_025161.6
FAH	C	100.00	100.00		NM_000137.4
FAN1	C	100.00	100.00		NM_014967.5
FANCA	C	100.00	100.00		NM_000135.4
FANCB	C	100.00	100.00		NM_001018113.3
FANCC	C	100.00	100.00		NM_000136.3
FANCD2	C	99.98	100.00		NM_001018115.3
FANCE	C	100.00	100.00		NM_021922.3
FANCF	C	100.00	100.00		NM_022725.4
FANCG	C	100.00	100.00		NM_004629.2
FANCI	C	100.00	100.00		NM_001376911.1
FANCL	C	99.94	99.95		NM_018062.4
FANCM	C	100.00	100.00		NM_020937.4
FAS	C	100.00	100.00		NM_000043.6
FH	C	100.00	100.00		NM_000143.4
FLCN	C	99.91	100.00		NM_144997.7
GALNT12	C	98.18	99.54		NM_024642.5
GATA2	C	100.00	100.00		NM_032638.5
GPC3	C	100.00	100.00		NM_004484.4
GREM1	C	100.00	100.00		NM_013372.7
HMBS	C	100.00	100.00		NM_000190.4
HOXB13	C	100.00	100.00		NM_006361.6
IPMK	C	100.00	100.00		NM_152230.5
ITK	C	100.00	100.00		NM_005546.4
KIT	C	99.99	100.00		NM_000222.3
LZTR1	C	98.92	99.83		NM_006767.4
MAD2L2	C	99.91	99.98		NM_006341.4
MAX	C	100.00	100.00		NM_002382.5
MBD4	C	100.00	100.00		NM_001276270.2
MCM9	C	100.00	100.00		NM_017696.3
MEN1	C	100.00	100.00		NM_001370259.2
MET	C	100.00	100.00		NM_000245.4
MITF	C	100.00	100.00		NM_001354604.2
MLH1	C	99.95	100.00		NM_000249.4
MLH3	C	100.00	100.00		NM_001040108.2
MSH2	C	99.86	99.98		NM_000251.3
MSH3	C	99.96	100.00		NM_002439.5
MSH6	C	100.00	100.00		NM_000179.3
MTAP	C	100.00	100.00		NM_002451.4
MUTYH	C	100.00	100.00		NM_001048174.2
NBN	C	99.99	100.00		NM_002485.5
NF1	C	97.52	97.54		NM_001042492.3
NF2	C	100.00	100.00		NM_000268.4
NSD1	C	100.00	100.00		NM_022455.5
NTHL1	C	99.96	100.00		NM_002528.7
PALB2	C	99.99	100.00		NM_024675.4
PAX5	C	99.97	100.00		NM_016734.3
PDGFRA	C	100.00	100.00		NM_006206.6
PHOX2B	C	95.3	98.4		NM_003924.4
PIK3CA	C	100.00	100.00		NM_006218.4
PMS2	C	78	78.84		NM_000535.7
POLD1	C	99.99	100.00		NM_002691.4
POLE	C	99.99	100.00		NM_006231.4
POLH	C	100.00	100.00		NM_006502.3
POT1	C	100.00	100.00		NM_015450.3
PRDM10	C	100.00	100.00		NM_199437.2
PRF1	C	100.00	100.00		NM_001083116.3
PRKAR1A	C	100.00	100.00		NM_002734.5
PTCH1	C	100.00	100.00		NM_000264.5
PTCH2	C	99.3	99.89		NM_003738.5
PTEN	C	100.00	100.00		NM_000314.8
PTPN11	C	100.00	100.00		NM_002834.5
RAD50	C	99.98	100.00		NM_005732.4
RAD51	C	100.00	100.00		NM_002875.5
RAD51C	C	99.99	100.00		NM_058216.3
RAD51D	C	100.00	100.00		NM_002878.4
RB1	C	99.98	100.00		NM_000321.3
RECQL4	C	100.00	100.00		NM_004260.4
REST	C	100.00	100.00		NM_005612.5
RET	C	100.00	100.00		NM_020975.6
RHBDF2	C	100.00	100.00		NM_001005498.4
RMRP
RNF139	C	100.00	100.00		NM_007218.4
RNF43	C	100.00	100.00		NM_017763.6
RUNX1	C	100.00	100.00		NM_001754.5
SBDS	C	100.00	100.00		NM_016038.4
SDHA	C	99.98	100.00		NM_004168.4
SDHAF2	C	100.00	100.00		NM_017841.4
SDHB	C	99.62	100.00		NM_003000.3
SDHC	C	100.00	100.00		NM_003001.5
SDHD	C	100.00	100.00		NM_003002.4
SH2D1A	C	99.9	100.00		NM_002351.5
SLX4	C	100.00	100.00		NM_032444.4
SMAD4	C	100.00	100.00		NM_005359.6
SMARCA4	C	99.99	100.00		NM_003072.5
SMARCB1	C	100.00	100.00		NM_003073.5
SMARCE1	C	100.00	100.00		NM_003079.5
SOS1	C	99.99	100.00		NM_005633.4
SPRED1	C	100.00	100.00		NM_152594.3
STK11	C	100.00	100.00		NM_000455.5
SUFU	C	100.00	100.00		NM_016169.4
TERF2IP	C	100.00	100.00		NM_018975.4
TERT	C	100.00	100.00		NM_198253.3
TMEM127	C	100.00	100.00		NM_017849.4
TP53	C	100.00	100.00		NM_000546.6
TRIM37	C	99.89	99.99		NM_015294.6
TRIP13	C	100.00	100.00		NM_004237.4
TSC1	C	100.00	100.00		NM_000368.5
TSC2	C	99.98	99.99		NM_000548.5
VHL	C	100.00	100.00		NM_000551.4
WAS	C	99.81	100.00		NM_000377.3
WRN	C	100.00	100.00		NM_000553.6
WT1	C	99.92	100.00		NM_024426.6
XPA	C	100.00	100.00		NM_000380.4
XPC	C	100.00	100.00		NM_004628.5
XRCC2	C	100.00	100.00		NM_005431.2

Indicatie(s)
Tumorsyndromen

** Voor informatie over eerdere versies van dit panel neem contact op met het laboratorium Genoomdiagnostiek

*** NGS panel genen kunnen met verschillende kwaliteit worden geanalyseerd. Meer informatie over testkwaliteit type A, C or A/C